Pengaruh Pemberian Ekstrak Bengkuang (Pachyrhizus Erosus) sebagai Antioksidan terhadap Kadar Kolesteroltinggi pada Mencit (Mus Musculus)

Roushandy Asri Fardani; Ika Nurfajri Mentari; Eka Fitria

doi:10.55681/saintekes.v3i2.327

Authors

Roushandy Asri Fardani Politeknik Medica Farma Husada Mataram, Mataram, Indonesia
Ika Nurfajri Mentari Politeknik Medica Farma Husada Mataram, Mataram, Indonesia
Eka Fitria Politeknik Medica Farma Husada Mataram, Mataram, Indonesia

DOI:

https://doi.org/10.55681/saintekes.v3i2.327

Keywords:

Cholesterol, Jicama, Mice

Abstract

High cholesterol levels in the blood are a serious problem because they are a risk factor for various non-communicable diseases such as heart disease, stroke and diabetes mellitus. Empirically, the secondary metabolic contents of jicama such as saponins& flavonoids have their respective properties. Saponin functions to bind cholesterol with bile acids so that it can reduce cholesterol levels. The results of the antioxidant activity test, the IC50 value of jicama extract is 115.20 mg/mL, which indicates that the antioxidant activity of jicama extract is classified as a moderate antioxidant. The results of measuring cholesterol levels after treatment showed that there was a decrease in cholesterol levels after giving jicama extract treatment in each group, seen in treatment 1 (P1) at 113.4 with a difference of 2.6 from cholesterol before administration, treatment 2 (P2) at 110.8 with a difference of 4.6 of cholesterol before administration, treatment 3 (P3) was 110.6 with a difference of 7.6 from cholesterol before administration of jicama extract, positive control (K+) was 108.4 with a difference of 30.2 from cholesterol before administration, negative control (K-) was 122.6 with a difference of 0.2 antioxidants from purple cabbage, namely 115.20 μg/mL. The antioxidant activity of purple cabbage is in the very strong category and vitamin C is in the very strong category.

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References

Arasj, D. F., Nurhamidah, & Oenzil, F. (2006). Pengaruh Pemberian Pati Bengkuang Terhadap Penurunan Kadar Gula Darah Tikus Putih Diabetes. 1–6.

Attazqiah, R. N., Siti, N., Ambarwati, S., Studi, P., Tiga, D., Rias, T., Teknik, F., & Jakarta, U. N. (2019). Studi Literatur : Pemanfaatan Ekstrak Kulit Buah Manggis ( Garcinia Mangostana L .) Untuk Perawatan Kulit. 1–10.

Barung, E. N., Schaduw, J., & Rintjap, D. S. (2003). Uji Aktivitas Antioksidan Dan Efek Penurunan Kolesterol Darah Dari Β-Karoten Buah Salak (Salacca Zalacca (Gaertner) Voss) Pada Tikus Putih (Rattus Norvegicus L.) Elisabeth.

Farida, Y., Qodriah, R., Widyana, A. P., & Ifani, Z. (2021). Uji Aktivitas Antioksidan, Uji Antikolesterol, Dan Toksisitas Dari Ekstrak Etanol Daun Kemuning (Murraya Paniculata L.Jack). 6(Suppl 1), 24–31.

Gunawan, A. (2020). Pengaruh Kombinasi Ekstrak Kulit Buah Pisang Ambon (Musa Paradisiaca L. ) Dan Bengkoang ( Pachyrhizus Erosus (L.)Urb.) Terhadap Kadar Gula Darah Mencit Putih Jantan (Mus Musculus L) karya.

Hadi, R., Juswono, U. P., & Widodo, C. S. (2015). Pengaruh Bengkuang (Pachyrhizus Erosus L. Urban) Dan Lidah Buaya (Aloe Vera) Terhadap Kandungan Radikal Bebas Pada Daging Ayam Yang Diradiasi Dengan Sinar Ultraviolet. 1–4.

Lister, I. N. E. (2021). Perbandingan Uji Efektivitas Ekstrak Bengkuang Terhadap Bakteri Propionibacterium Acnes. 4(1), 60–68.

Muqowwiyah, L. Z., & Dewi, R. K. (2021). Potensi Ekstrak Daun Alpukat Sebagai Anti Kolesterol. 1(3), 403–412.

Umami, S. R., Hapizah, S. S., Fitri, R., & Hakim, A. (2016). Uji Penurunan Kolesterol Pada Mencit Putih (Mus Musculus) Secara In-Vivo Menggunakan Ekstrak Metanol Umbi Talas (Colocasia Esculenta L) Sebagai Upaya Pencegahan Cardiovascular Disease. Xi(2), 121–124.

Yoeantafara, A., & Martini, S. (2017). Pengaruh Pola Makan Terhadap Kadar Kolesterol. 13, 304–309.